Recombinant Mouse EGFR Protein (Fc Tag)(Active) Size: 100μg Catalogue Number: PKSM040366-100 Citations, Manuals and MSDS Available upon request. Abbreviation: EGFR Target Symptom: 9030024J15Rik; AI552599; Erbb; Errb1; Errp; wa-2; wa2; Wa5 Target Species: Mouse Expression Host: HEK293 Cells Application: ELISA Fusion Tag: C-hFc UNIProt ID: Q01279 Accession: Q01279 Background: As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α , betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. Activity: Measured by its ability to bind human EGF in a functional ELISA. Sequence: Met 1-Ser 647 Purity: > 90 % as determined by reducing SDS-PAGE. Formulation: Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. Reconstitution: Please refer to the printed manual for detailed information. Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method. Calculated MW: 96 kDa Observed MW: 130 kDa Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. Shipping: This product is provided as lyophilized powder which is shipped with ice packs. Research Use Only